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Figure 4. Area under the time–activity curve (AUC) of 11C-DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide) PET scan prior to and after 120-h infusion of DACA at the maximum tolerated dose (MTD). The lack of substantial change implies that there is no evidence of a saturable process either systemically or within the tumour, despite reaching the MTD.





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