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Figure 3. Treatment of clinical radiation nephropathy with the angiotensin converting enzyme (ACE) inhibitor, captopril. The patient received a bilateral renal dose of 9.8 Gy in 9 fractions at 0.08–0.20 Gy min–1 as part of the total body irradiation used in the preparatory regimen for bone marrow transplantation (BMT). After 7 months, the patient developed BMT nephropathy as confirmed by biopsy (see Figure 2 in Cohen and Robbins [16]). At 12 months, captopril therapy was begun at a dose of 12.5 mg daily and has been continued at that dose. Renal function is shown as 100 x the reciprocal of the serum creatinine. Stabilisation of kidney function is evident from the significant (p<0.001) change in the slope.
