British Journal of Radiology (2006) 79, 540-541
© 2006 British Institute of Radiology
doi:
Molecular basis of breast cancer: prevention and treatment. By J Russo and I H Russo. pp. xiv+448, 2004 (Springer-Verlag, Berlin, Heidelberg, New York), £154.00 ISBN 3-540-00391-6
K Faulkner
This magnum opus covers the entire molecular basis of breast cancer in ten self-contained chapters. Epidemiological considerations in breast cancer are covered in chapter one. This reviews geographical influences, ionizing radiation, electromagnetic field, reproductive aspects and environmental factors, including smoking and alcohol. This is an interesting introduction to the subject.
The development of the breast is described in the second chapter in great detail. A knowledge of breast development is critical in understanding breast cancer risks, such as its inverse relationship with early parity. The level and depth of information is excellent. The changes in breast structure from intrauterine life to old age are described in detail.
Endocrine control of breast development is covered in chapter three. The response of breast tissue to oestrogen and other hormones is summarized. The role of oestrogen in breast cancer is described in chapter four. Increased risk of breast cancer has been associated with the early onset of menstruation, nulliparity or delayed first childbirth, short duration of breast feeding, late menopause, use of hormone therapy and increased bone density. All of which suggest that prolonged exposure to female sex hormones may be a cause. The implications of this are comprehensively covered. The pathologenesis of breast cancer is described in the fifth chapter. Two chapters cover animal and in vivo models of human breast cancer.
The final two chapters cover preventative strategies in breast cancer and the new paradigm in breast cancer prevention. Four basic preventative strategies: physioprevention, bioprevention, chemoprevention and socioprevention are considered. The mechanisms for each are described and examples of a risk reduction technique described.
The book is well written in an easy to follow style. It is profusely illustrated with numerous figures, many of which are in colour. The high production values explain why the book costs over £150. Its high cost will inevitably limit the number of libraries and individuals who may purchase it, which is a pity. Most libraries would benefit from having this textbook on their shelves. It is an excellent book which will be of interest to both researchers and lay individuals wanting to obtain background information on breast cancer.
