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Figure 5. Two-dimensional visualization of the simulated response of a radiosensitive clinical glioblastoma multiforme tumour to the standard fractionation scheme, for a range of clonogenic cell density (CCD). The figure shows a centrally located horizontal slice of a tumour with clonogenic cell density equal to 1xCCD( = 104 cells mm–3) (a) 3 fictitious days after the beginning of the radiotherapy course (e) 5 fictitious days after the beginning of the radiotherapy course, (i) 8 fictitious days after the beginning of the radiotherapy course. A centrally located horizontal slice of a tumour with clonogenic cell density equal to 2xCCD (b) 3 fictitious days after the beginning of the radiotherapy course (f) 5 fictitious days after the beginning of the radiotherapy course (j) 8 fictitious days after the beginning of the radiotherapy course. A centrally located horizontal slice of a tumour with clonogenic cell density equal to 3xCCD, (c) 3 fictitious days after the beginning of the radiotherapy course, (g) 5 fictitious days after the beginning of the radiotherapy course, (k) 8 fictitious days after the beginning of the radiotherapy course. A centrally located horizontal slice of a tumour with clonogenic cell density equal to 4xCCD, (d) 3 fictitious days after the beginning of the radiotherapy course, (h) 5 fictitious days after the beginning of the radiotherapy course, (l) 8 fictitious days after the beginning of the radiotherapy course. For this specific case, the LQ model parameters of the tumour are in accordance with a GBM cell line with known mt p53 gene. Irradiation schedule starts on the first day of the first week of treatment. Colour Code: dark grey: proliferating cell layer, light grey: dormant cell layer (G0), white: dead cell layer. The colouring criterion "99.8%" used to visualize the predictions has been defined as follows. "For a geometrical cell of the discretising mesh, if the percentage of dead cells is lower than 99.8% then {if percentage of proliferating cells > percentage of G0 cells, then paint the geometrical cell dark grey (proliferating cell layer)}, else paint the geometrical cell light grey (G0 cell layer) else paint the geometrical cell white (dead cell layer)".
