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Figure 4. Simulation predictions of(a) the number of proliferating and (b) the total number of proliferating, dormant and dead mt p53 tumour cells in the case of the standard fractionation scheme (2 Gy once a day, 5 days per week, 60 Gy in total) for different clonogenic cells densities (CCD = 104 cells mm–3). Irradiation schedule starts on the first day of the first week of treatment. It should be stressed that reproductively dead cells and their offspring that are still cycling are considered proliferating until their ultimate biological death. The periodicity noticed on all graphs reflects the weekly irradiation periodicity. It is noted that no irradiation takes place during the weekend.
