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Figure 1. (a) A B-mode image of the right lobe of the liver obtained at 3 min 6 s following the administration of Levovist®. There is an indeterminate heterogeneous area (between arrows) that is poorly defined but suspicious of malignancy in a patient with a known primary tumour outside the liver. (b) Using a late-phase destructive mode (Agent Detection Imaging, ADI®; Siemens, Mountain View, CA), there is transient destruction of the microbubble contrast agent in normal liver tissue, but absence of microbubble contrast in the tumour appears as "two-black holes" (arrow).
