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Figure 2. VX-2 tumour in the rabbit liver, Case 4. (a) Non-contrast tissue harmonic image. The one detected tumour nodule had an isoechoic appearance with a central hypoechoic area (arrow, white). The ultrasound pattern of the liver parenchyma was heterogeneous, but other tumour nodules were not clear. (b) Contrast-enhanced pulse subtraction harmonic image with Definity. Homogeneous enhancement was seen in the liver parenchyma. Two tumours were observed as unenhanced nodules with clear delineation, with one of them (right side) showing peripheral enhancement (arrows, white). Small tumours were demonstrated as unenhanced nodules around the two tumour nodules (arrows, grey). (c) Histopathological findings. There were two implanted tumour nodules, 14.4 mm and 19 mm, in the liver (arrows, white and black). Small tumour nodules were observed around the implanted tumours, and were believed to be metastatic tumour nodules (arrows, grey). The tumour tissues were necrotic, but one of them (arrow, black) had tumour vessels in the peripheral area corresponding to the peripheral enhancement in (b).
