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Figure 1. VX-2 tumour in the rabbit liver, Case 11, right lobe. (a) Non-contrast tissue harmonic image. One tumour nodule with heterogeneous ultrasound pattern was observed (arrow). The margin of the tumour nodule was not clear. Other tumour nodules were not detected. (b) Contrast-enhanced pulse subtraction harmonic image with Definity. One tumour nodule was observed as an unenhanced nodule with peripheral enhancement (arrow, white), and small tumour nodules were demonstrated as unenhanced nodules around this nodule (arrows, grey). All the tumour nodules were delineated clearly with homogeneous enhancement of the surrounding liver parenchyma. (c) Histopathological findings. One implanted tumour nodule 18 mm in size (arrow, white) and daughter tumour nodules (arrows, black) were observed. The implanted tumour was hypervascular in the peripheral area, corresponding to the peripheral enhancement in (b) and it was necrotic in the central area.
