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Figure 3. Non-rigid registration applied to intersubject brain matching. The top row shows two selected slices from a T1 weighted MR-volume of a normal subject. The middle row shows the same slices from a similar image of a different subject. The bottom row shows the result of using non-rigid (fluid) registration to match the second subject to the first. The major neuroanatomical features have been brought into good correspondence. A closer inspection shows that not all of the fine cortical structure has been matched successfully. This is a typical finding when comparing brain images across subjects due to population variation in the geometry of the cortical surface. Note, the left and right views are not of the same scale.