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Figure 6. Results of studying locally advanced rectal cancer using quantitative diffusion weighted imaging. A typical low-b value image (top left) of a large tumour and the resulting diffusion image (top right). The two graphs demonstrate that those tumours with a low apparent diffusion coefficient (ADC) (and by implication of higher cellularity) prior to treatment are more likely to respond to chemotherapy (bottom left) and chemoradiation (bottom right) than those that are not. Based on evidence from animal tumours we have argued that the ADC measurements in this situation are a surrogate marker for necrosis. Graphs reprinted with permission from Elsevier [11].
