Figure 5. Initial maximum acute changes (mean±SEM) in pulmonary artery pressure from baseline in chronic hypoxic pulmonary hypertensive rats in response to radiographic contrast media. (a)Schematic diagram of the changes in Ppa in response to 0.5 ml of iopromide shows an initial fall followed by a rise in Ppa within 2 min of exposure (*p<0.05 in comparison with baseline). (b) Schematic diagram of the changes in Ppa in response to iotrolan shows an initial fall followed by a rise in Ppa with 0.1 ml and 0.3 ml of iotrolan, but no initial fall and an immediate rise in Ppa with a 0.5 ml dose (*p<0.05 in comparison with baseline). (c) Schematic diagram of the changes in Ppa in response to ioxaglate shows a significant sustained fall in Ppa that lasted for approximately 20 min (**p<0.01 in comparison with baseline). (N.B. The time-scale of the schematic diagram is the same for each figure.)
