Figure 3. Rise in pulmonary artery pressure (Ppa) (mean±SEM) in response to a cumulative volume of 0.95 ml of radiographic contrast media (RCM), mannitol solutions (osmolar control) or normal saline (volume control) in normal rat isolated perfused lung preparation (normoxic ventilation) from baseline (n=6–9). IOP, iopromide; IOT, iotrolan; IOX, ioxaglate; D, diatrizoate; IOPM, IOTM and IOXM, RCM-matched mannitol (osmolar control) solutions (for diatrizoate the osmolar control solution DM was saturated mannitol); S, normal saline; *Saline vs D, IOX, IOT and SM (p<0.05); **RCM vs matched mannitol (p<0.01). All tested solutions, with the exception of iotrolan mannitol control and normal saline, induced a significant (p<0.05) rise in Ppa compared with the baseline.
