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British Journal of Radiology (2005) Supplement_28, 42-49
© 2005 British Institute of Radiology
doi: 10.1259/bjr/59640473
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PET for response assessment in oncology: radiotherapy and chemotherapy

W A Weber, MD

Department of Molecular and Medical Pharmacology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA



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  		Figure 1. FDG-PET and CT scans of a patient with non-small cell lung cancer demonstrating a good partial response to chemotherapy. There is a 61% decrease in FDG uptake 3 weeks after initiation of chemotherapy. Reproduced with kind permission of the American Society of Clinical Oncology from: Weber WA, et al. Positron emission tomography in non-small-cell lung cancer: prediction of response to chemotherapy by quantitative assessment of glucose use. J Clin Oncol 2003;21:2651–7.

 


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  		Figure 2. FDG-PET and CT studies in patients with gastric cancer treated by pre-operative chemotherapy. The tumour demonstrates intense FGD uptake prior to therapy. Two weeks after initiation of therapy, tumour FGD uptake has been reduced to background levels. Histological evaluation of the resected tumour specimen revealed less than 10% viable tumour cells after 3 months of chemotherapy. Reproduced with kind permission of the American Society of Clinical Oncology from: Ott K, et al. Prediction of response to preoperative chemotherapy in gastric carcinoma by metabolic imaging: results of a prospective trial. J Clin Oncol 2003;21:4604–10.

 


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  		Figure 3. Kaplan–Meier plot showing overall survival of patients with gastric cancer treated by pre-operative chemotherapy (CTx). Patients with a metabolic response 14 days after initiation of therapy are characterised by a markedly better prognosis than patients without a metabolic response. Reproduced with kind permission of the American Society of Clinical Oncology from: Ott K, et al. Prediction of response to preoperative chemotherapy in gastric carcinoma by metabolic imaging: results of a prospective trial. J Clin Oncol 2003;21:4604–10.

 




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