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Involvement of the central nervous system in radiation-induced multi-organ dysfunction and/or failure

¹ Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses and ² Centre de Recherches du Service de Santé des Armées, La Tronche, France

View larger version (15K): [in a new window]   Figure 1. Kinetics of interleukin-8 (IL-8) production in serum during early and late phases following 4 Gy, 6 Gy and 8 Gy mixed neutron– whole body irradiation in a non-human primate model.

View larger version (17K): [in a new window]   Figure 2. Kinetics of C-reactive protein release in serum during early and late phases following 2 Gy, 4 Gy, 6 Gy and 8 Gy mixed neutron– whole body irradiation in a non-human primate model.

View larger version (62K): [in a new window]   Figure 3. The classical concept of the systemic inflammatory response syndrome (SIRS) as a common response to many stressors, including irradiation. Modified from P-O Nyström [5].

View larger version (12K): [in a new window]   Figure 4. Kinetics of interleukin-1 (IL-1) and IL-1 production in the cerebral cortex during the early phase following 5 Gy whole body irradiation in mice. Adapted from C Marquette et al [15].

View larger version (15K): [in a new window]   Figure 5. Interleukin-1 (IL-1) concentrations measured in the hypothalamus and the hippocampus 6 h after 15 Gy partial body irradiation (protected head) in non-vagotomised (non-VGX) or vagotomised (VGX) rats. Adapted from C Marquette et al [26].

View larger version (42K): [in a new window]   Figure 6. New approach to the radiation-induced central nervous system (CNS) inflammatory response syndrome and its interactions with the systemic inflammatory response syndrome (SIRS).