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Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts

¹ Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ, ² School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Lewes Road, Brighton, BN2 4GJ, ³ Radiotherapy/Clinical Oncology, St. Bartholomew's Hospital, 25 Bartholomew Close, West Smithfield, London, EC1A 7BE, UK

View larger version (24K): [in this window] [in a new window]   Figure 1. Cumulative frequency plots of the types of strain used in this investigation. The percentage of strains with 5 Gy survival below a given value is plotted. , normal strains; , xeroderma pigmentosum; , Cockayne syndrome;, combined xeroderma and Cockayne syndrome;, ataxia-telangiectasia.

View larger version (31K): [in this window] [in a new window]   Figure 2. D10 values for XP (), CS (), XP/CS () and AT ( ) strains used in this investigation. (The number of standard protocol survival curves that were performed is given in brackets.)

View larger version (21K): [in this window] [in a new window]   Figure 3. D10 values for normal fibroblast strains used in this study. (The number of standard protocol survival curves that were performed is given in brackets.)