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Longitudinal imaging in dementia

Dementia Research Centre, 8–11 Queen Square, London WC1N 3BG, UK

View larger version (69K): [in this window] [in a new window]   Figure 1. Brain boundary shift integral showing change over a year in(a) a healthy control and (b) an individual with sporadic Alzheimer's disease – with hippocampal and temporal neocortical loss accompanied by ventricular enlargement.

View larger version (102K): [in this window] [in a new window]   Figure 2. Baseline scans(left) and voxel-compression maps (right) of individuals with (a) sporadic Alzheimer's disease, (b) frontotemporal dementia, (c) progressive supranuclear palsy and (d) Creutzfeldt–Jakob disease. The individual with Alzheimer's disease shows bilateral diffusely increased rates of atrophy, whereas the subject with frontotemporal dementia has marked left-greater-than-right rates of loss. (c) and (d) show increased mid-brain atrophy rates in the patient with progressive supranuclear palsy, and cerebellar involvement in Creutzfeldt–Jakob disease.