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SPECT imaging in dementia

¹ Radiopharmaceutical Research & Development, West of Scotland Radionuclide Dispensary, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, ² Foundation Chair of Old Age Psychiatry, Oxford University, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK

View larger version (22K): [in this window] [in a new window]   Figure 1. 4–β2 Nicotinic receptor binding 4 h after injection of 5-123I-A-85380, examined with single photon emission CT (maximum intensity projection). Left to right: rotating from facing left to facing right. Greatest tracer uptake in thalamus, brain stem and cerebellum.

View larger version (55K): [in this window] [in a new window]   Figure 2. Timeline of guidelines. PET, positron emission tomography; SPECT, single photon emission CT.

View larger version (19K): [in this window] [in a new window]   Figure 3. (a) 95% confidence intervals of weighted sensitivity and (b) 95% confidence intervals of weighted specificity. The graphs summarize the results of N studies each comparing AD patients VaD, FTD and other patients (O; e.g. those with depression) and healthy controls (C) – note low sensitivity against non-demented patient controls. (c) 95% confidence intervals of mean ages (years) in the study groups in each of the four comparisons illustrated in (a) and (b). (All data from [41].)