BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
British Journal of Radiology (2007) 80, S2-S6
© 2007 British Institute of Radiology
doi: 10.1259/bjr/60507340
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lindsay, K J
Right arrow Articles by Wright, E G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lindsay, K J
Right arrow Articles by Wright, E G

The genetic basis of tissue responses to ionizing radiation

K J Lindsay, BSc P J Coates, PhD S A Lorimore, BSc and E G Wright, PhD, FRCPath, FRSE

Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK


Figure 1
View larger version (59K):
[in this window]
[in a new window]

  		Figure 1. (a), (b) and (c) are examples of immunohistochemistry staining on C57BL/6 spleen tissue. (a) p53 staining 3 h after 1 Gy {gamma} radiation, (b) p21 staining 3 h after 1 Gy {gamma} radiation, (c) Bax staining 6 h after 1 Gy {gamma} radiation. (d) A western blot of p53 C57BL/6 and DBA/2 spleen tissue at the indicated timepoints post 1 Gy {gamma} radiation.

 

Figure 2
View larger version (19K):
[in this window]
[in a new window]

  		Figure 2. Mean number of apoptotic cells counted in 10 fields of splenic white pulp. This graph shows the splenic apoptosis counts of the C57BL/6, DBA/2 and CBA/Ca mouse strains at the indicated timepoints following 0.5 Gy {gamma} radiation.

 

Figure 3
View larger version (26K):
[in this window]
[in a new window]

  		Figure 3. Mean number of apoptotic cells counted in 10 fields of splenic white pulp, and 20 crypts of the small intestine and the colon on a logarithmic scale.(a) C57BL/6-like high apoptosis group of the test cohort, (b) DBA/2-like low apoptosis group of the test cohort. Table (c) illustrates the correlation coefficients (r) between each of the tissues.

 

Figure 4
View larger version (35K):
[in this window]
[in a new window]

  		Figure 4. 2D gel electrophoresis western blots with 1/5000 CM5 anti-p53 antibody on C57BL/6 intestinal tissue. (a) Colon control, (b) colon 1 h after 4 Gy {gamma}-irradiation, (c) small intestine control, (d) small intestine 1 h after 4 Gy {gamma}-irradiation.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 2007 by the British Institute of Radiology.