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British Journal of Radiology (2007) 80, e234-e237
© 2007 British Institute of Radiology
doi: 10.1259/bjr/33539044
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Myxoid neurofibromas of the breast: mammographical, sonographical and MRI appearances

G Gokalp, MD 1,2 B Hakyemez, MD 1 E Kizilkaya, MD 2 and A Haholu, MD, PhD 3

1 Department of Radiology, Uludag University Medical School, Gorukle, Bursa and Departments of, 2 Radiology, 3 Pathology, GATA Haydarpasa Training Hospital, Uskudar, Istanbul, Turkey


Figure 1
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  		Figure 1. Craniocaudal mammogram showing a few non-calcified, oval masses partly obscured by surrounding fibroglandular breast tissue in the left breast. Masses cause lobulations of cutaneous tissue and asymmetrical enlargement of the breast.

 

Figure 2
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  		Figure 2. Sonography demonstrating well-defined, oval, hypoechoic, solid masses with slight posterior acoustic enhancement within the left breast.

 

Figure 3
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  		Figure 3. Dynamic breast MRI.(a) Sagittal pre-contrast three-dimensional T1 weighted fast low-angle shot (FLASH) sequence showing a low intensity, oval, well-defined mass (arrow). (b) Axial T2 weighted fast spin-echo image showing a high intensity mass (arrow). (c) Subtraction of the post-contrast from the pre-contrast image displays a homogeneously enhancing lesion. (d) The signal-to-time curve in this enhanced mass reveals a strong initial signal intensity increase of more than 100% in the first 3 min, followed by a gradual enhancement in the next few minutes (Type 1 curve).

 

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  		Figure 4. (a) The histological appearance (x10; H&E stain) of a neurofibroma reveals proliferation of nerve fibres and fibroblasts beneath the covering epidermis of breast skin. (b) Magnification of the same area (x20; H&E stain) shows cells dispersing in loose, disordered myxoid stroma.

 




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