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Inhibition of pseudointimal hyperplasia in swine TIPS models: the efficacy of local delivery of paclitaxel using a perforated balloon catheter

¹ Department of Radiology, Konkuk University Hospital, ² Departments of Diagnostic Radiology, ³ Pathology, Korea University, College of Medicine, Seoul, ⁴ Department of Diagnostic Radiology, Ajou University School of Medicine, Suwon, Korea

View larger version (64K): [in this window] [in a new window]   Figure 1. After successful portal vein puncture, contrast material was infused through a perforated balloon catheter and staining of contrast material(arrow) into parenchymal tract was confirmed.

View larger version (90K): [in this window] [in a new window]   Figure 2. Gross specimen of TIPS tract longitudinally bisected included the portal vein(PV), hepatic parenchyma, hepatic vein and inferior vena cava (IVC). (a) Gross specimen of the control group shows an occluded shunt filled with whitish and yellowish tissue (arrows). (b) The treatment group shows little occlusion relatively and a smooth surface in the internal surface of shunt (arrows).

View larger version (76K): [in this window] [in a new window]   Figure 3. Low-magnification photomicrograph of TIPS tract (magnification x40, haematoxylin and eosin stain). (a) In the control group, from defects caused by stent struts to the lumen, there turned out to be a significant proliferation of fibroblast, which demonstrates pseudointimal hyperplasia (arrow). (b) In the treatment group, there was significantly less proliferation of fibroblast than in the control group (arrow).