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First published online July 9, 2007
British Journal of Radiology (2007) 80, 593-602
© 2007 British Institute of Radiology
doi: 10.1259/bjr/20129205

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Segmental disorders of the nephron: histopathological and imaging perspective

S R Prasad, MD 1 V R Narra, MD 2 R Shah, MD 1 P A Humphrey, MD, PhD 3 J Jagirdar, MD 4 J R Catena, MD 1 N C Dalrymple, MD 1 and C L Siegel, MD 2

1 Department of Radiology, University of Texas Health Science Center @ San Antonio, San Antonio, TX, 2 Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, MO, 3 Department of Pathology, Washington University in St Louis, St Louis, MO, 4 Department of Pathology, University of Texas Health Science Center @ San Antonio, San Antonio, TX, USA


Figure 1
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Figure 1. Schematic diagram representing segmental localization of various renal disorders within the nephron. Different components of the nephrons including the glomerulus, proximal convoluted tubule(blue), distal convoluted tubule (green) and collecting duct (yellow) and their associated conditions are demonstrated (courtesy of Robert Chandler, MD, UTHSCSA, San Antonio, TX).

 

Figure 2
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Figure 2. Juxtaglomerular cell tumour of the kidney. Delayed phase, contrast-enhanced CT scan shows an expansile, relatively homogeneous, hypoattenuating mass in the right kidney (arrows).

 

Figure 3
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Figure 3. Clear cell renal cell carcinoma. Contrast-enhanced CT scan during corticomedullary phase shows a heterogeneous, hypervascular right renal mass (arrows) with areas of necrosis and haemorrhage (arrowhead).

 

Figure 4
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Figure 4. (a) Papillary renal cell carcinoma. Contrast-enhanced CT scan during the corticomedullary phase shows a left renal hypoattenuating solid mass (arrow) with foci of calcification (arrowhead). (b) Papillary renal cell carcinoma. Coronal gadolinium-enhanced T1 weighted Gradient echo MRI shows a uniform, hypovascular solid mass (arrow) in the upper pole of the left kidney.

 

Figure 5
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Figure 5. Bilateral renal oncocytomas. Delayed phase contrast-enhanced CT scan shows bilateral, hypoattenuating solid renal masses (arrows). While the right renal mass is uniformly hypoattenuating, the left renal mass shows the characteristic central stellate scar (arrowhead).

 

Figure 6
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Figure 6. Chromophobe renal cell carcinoma. Coronal, gadolinium-enhanced T1 weighted GRE image of the right kidney during the nephrographic phase shows a large, expansile mass (arrows) that shows heterogeneous contrast enhancement (arrowhead).

 

Figure 7
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Figure 7. Collecting duct carcinoma of the kidney. Transverse, right renal sonogram shows an expansile, uniformly hypoechoic solid neoplasm(arrowheads). Arrow shows the right kidney.

 

Figure 8
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Figure 8. Collecting duct carcinoma of the kidney. Nephrographic phase, contrast-enhanced CT scan demonstrates a hypoattenuating, infiltrating neoplasm in the right kidney (arrow) with associated retroperitoneal lymphadenopathy (arrowhead).

 

Figure 9
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Figure 9. Renal medullary carcinoma. Nephrographic phase contrast-enhanced CT scan demonstrates a hypoattenuating, infiltrating neoplasm in the right kidney (arrow) with associated low-density retroperitoneal lymphadenopathy (arrowhead).

 

Figure 10
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Figure 10. Renal medullary nephrocalcinosis. Longitudinal right renal sonogram demonstrates hyperechoic pyramids(arrows) consistent with medullary nephrocalcinosis.

 

Figure 11
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Figure 11. Medullary sponge kidney. Intravenous urography shows the characteristic medullary"brush" configuration of the dilated collecting ducts in the right kidney (arrows).

 

Figure 12
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Figure 12. (a) Autosomal dominant polycystic kidney disease complicated by the development of a renal cell carcinoma. Coronal T2 weighted MRI shows innumerable cysts that replace both the kidneys (arrowheads). Incidentally seen is a hypointense mass in the upper pole of the right kidney (arrows). (b) Autosomal dominant polycystic kidney disease complicated by the development of a renal cell carcinoma. Coronal, gadolinium-enhanced T1 weighted two-dimensional GRE MRI shows predominantly peripheral contrast enhancement of the mass in the upper pole of the right kidney (arrowheads).

 





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