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An efficient method for calculating kinetic parameters in a dual-input single-compartment model

Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan

View larger version (10K): [in this window] [in a new window]   Figure 1. Illustration of a dual-input single-compartment model. Ca(t), Cp(t) and CL(t) represent the concentrations of the contrast agent (CA) at time t in the hepatic artery or aorta, the portal vein, and the liver region of interest, respectively. K1a, K1p and k2 are the rate constants for the exchanges of CA from the hepatic artery or aorta to the liver, from the portal vein to the liver, and from the liver to plasma, respectively.

View larger version (33K): [in this window] [in a new window]   Figure 2. Typical examples ofCa(t), Cp(t) and CL(t). In this case, K1a, K1p, k2, the capillary plasma volume per unit volume of tissue (V0) and the signal-to-noise ratio (SNR) were assumed to be 20 ml/100 ml/min, 80 ml/100 ml/min, 4 min–1, 0 ml/100 ml and 20, respectively.