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First published online September 27, 2006
British Journal of Radiology (2007) 80, 307-320
© 2007 British Institute of Radiology
doi: 10.1259/bjr/52670770
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3D MRI in multiple sclerosis: a study of three sequences at 3 T

R J Mills, MRCP 1 C A Young, FRCP 1 and E T S Smith, FRCP 2

Departments of 1 Neurology and 2 Neuroradiology, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK


Figure 1
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  		Figure 1. Coronal three-dimensional 3 T (a) T2 fluid attenuated inversion recovery (FLAIR), (b) T2 turbo spin echo (TSE) and (c) T1 inversion recovery (IR) images.

 

Figure 2
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  		Figure 2. Three-dimensional 3 T T2 fluid attenuated inversion recovery (FLAIR) orthogonal multiplanar reconstruction (MPR).

 

Figure 3
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  		Figure 3. Three-dimensional 3 T T2 turbo spin echo (TSE) orthogonal multiplanar reconstruction (MPR).

 

Figure 4
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  		Figure 4. Three-dimensional 3 T T1 inversion recovery (IR) orthogonal multiplanar reconstruction (MPR).

 

Figure 5
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  		Figure 5. Three-dimensional 3 T T1 inversion recovery (IR), post-contrast, orthogonal multiplanar reconstruction (MPR) (63-year-old female, duration of MS 27 years, EDSS 5.0, relapsing remitting disease).

 

Figure 6
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  		Figure 6. (a) 1.5 T two-dimensional T2 turbo spin echo (TSE) axial (5 mm thick, ~7 lesions), (b) 3 T two-dimensional T2 TSE axial (5 mm thick, ~5 lesions) and (c) reconstructed 3 T three-dimensional T2 TSE (1 mm thick, ~13 lesions) images of the same patient.

 

Figure 7
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  		Figure 7. (a) 1.5 T three-dimensional T2 turbo spin echo (TSE) (best window level shown) (1 mm thick, 6 lesions) and (b) 3 T three-dimensional T2 TSE, right (1 mm thick, 13 lesions) images of the same patient.

 

Figure 8
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  		Figure 8. 3 T reconstructed axialT2 turbo spin echo (TSE) showing a confluent area of diffuse increased signal typical of dirty appearing white matter (DAWM). Small punctate areas of higher signal can be seen within this, representing Virchow–Robin spaces.

 

Figure 9
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  		Figure 9. 3 T reconstructed axialT2 turbo spin echo (TSE) images showing white matter in (a) a normal subject and (b) a multiple sclerosis (MS) patient. (c) Also shown is the corresponding T1 image for the same MS patient. There appears to be a coarser signal texture, on the T2 image, in the MS patient which is not thought to be due simply to Virchow–Robin spaces.

 

Figure 10
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  		Figure 10. Coronal, axial and sagittal(a–c) T2 turbo spin echo (TSE) and (d–f) T1 inversion recovery (IR) images of a normal subject showing innumerable Virchow–Robin spaces in the white matter.

 




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