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¹²³I-IMT SPECT for evaluation of the response to radiation therapy in high grade gliomas: a feasibility study

¹ Department of Radiology, Nuclear Medicine and Radiooncology, Campus Virchow-Klinikum, ² Department of Radiation Therapy, Campus Mitte, ³ Department of Neurosurgery, Campus Virchow-Klinikum, University Clinic Charité, Berlin, Germany

View larger version (27K): [in this window] [in a new window]   Figure 1. A 47-year-old female patient (patient no.1) suffering from glioblastoma in the left frontal lobe presented 2 weeks after partial tumour resection. (a) The T1 weighted MR scan shows slight contrast media accumulations around the resection area. (b) Single photon emission computed tomography (SPECT) scan and (c) fused image demonstrate a high tracer uptake around the resection defect. (d) The control SPECT study following application of 40 Gy shows a reduction of the intratumoural 123I-methyltyrosine (IMT) uptake, as compared with the baseline study. The control investigation 7 months after completing the therapy (c) demonstrates no further changes of the tracer uptake in the lesion. In the follow up of 34 months, the patient was only slightly hindered by the tumour.

View larger version (9K): [in this window] [in a new window]   Figure 2. Amino acid transport under radiation therapy/at baseline in patients with high grade glioma in relation to survival. Changes in T/Bmean were not significantly correlated with survival: r (Spearman) = –0.1; p = 0.973.