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First published online February 15, 2007
British Journal of Radiology (2007) 80, 161-168
© 2007 British Institute of Radiology
doi: 10.1259/bjr/17112059
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Comparison of cerebral blood volume maps generated from T2* and T1 weighted MRI data in intra-axial cerebral tumours

H A Haroon, PHD 1 T F Patankar, MBBS, FRCR 1 X P Zhu, MD, PHD 2 K L Li, PHD 2 N A Thacker, PHD 1 M J Scott, PHD 1 and A Jackson, PHD, FRCR, FRCP 1

1 Division of Imaging Science and Biomedical Engineering, Faculty of Medical and Human Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK, 2 Department of Radiology, School of Medicine, University of California at San Francisco, San Francisco, California 94143, USA


Figure 1
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  		Figure 1. (a) High resolution post-contrast T1 weighted (volumetric T1 FFE / TR 24 ms / TE 11 ms) anatomical image showing an enhancing high grade glioma (patient 8). (b) Corresponding cerebral blood volume (CBV) map generated from T2*-weighted EPI dynamic susceptibility-enhanced data (T2* CBV) [values range 0–100%]. Related maps generated from T1 weighted fast field echo contrast-enhanced dynamic data of (c) Kfp [values range 0–1.2 min–1] and (d) T1 CBV (values range 0–100%). ((b),(c) and (d) use the same colour rendering table for display.)

 

Figure 2
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  		Figure 2. Corresponding(a) T1 CBV and a (b) T2* CBV maps showing a high grade glioma, the circle of Willis and middle cerebral arteries (patient 1). (c) High resolution post-contrast T1 weighted (volumetric T1 FFE / TR 24 ms / TE 11 ms) anatomical image showing the same location. ((a) and (b) use the same colour rendering table for display.)

 

Figure 3
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  		Figure 3. Comparison of the median measurement taken from enhancing tumour tissue ROIs on manually matched slices ofT1-CBV maps against T2*-CBV, for all our tumour cases. (r = 0.667, p<0.05).

 

Figure 4
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  		Figure 4. Pixel-by-pixel scattergram of a visually matched brain slice from the T1-CBV and T2*-CBV maps in patient 7, using a vascular region of normal brain only. The square-root of the values from the two maps is used to ensure uniform error and to expand the dynamic range of data for visualization (see text); (r = 0.92, p<0.001).

 

Figure 5
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  		Figure 5. Pixel-by-pixel scattergram generated from the same data as in Figure 4Go except that this has been produced by a pixel shuffling method between CBV maps to allow for spatial distortions in the T2*-CBV map (see text). (r = 0.96, p<0.001).

 




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