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A giant malignant peripheral nerve sheath tumour of the breast: CT and pathological findings

Departments of ¹ Radiology, ² Surgery and ³ Pathology, College of Medicine, Korea University, Korea University Guro Hospital, 97 Guro-dong, Guro-ku, Seoul, 152-703, Korea

View larger version (77K): [in this window] [in a new window]   Figure 1. A 56-year-old woman with malignant peripheral nerve sheath tumour of breast. (a) Gross findings of the tumour. The tumour involved the entire right breast, which suffered extensive necrosis and inflammation. (b) Axial CT image shows a heterogeneous soft tissue mass with multiple well-enhanced nodules at its periphery and extensive internal necrosis. (c) Sagittal reconstruction CT image shows the huge breast mass, which protruded beyond the skin, involving the pectoralis and intercostal muscles. (d) The photograph of the mastectomy gross specimen shows the necrotizing, heterogeneous, haemorrhagic, solid nature of the mass and of tumour with a flesh, myxoid and white-tan appearance in the mass periphery. (e) Photomicrograph of a histopathological specimen shows intersecting fascicles of spindle cells and the cellular fascicles alternated with hypocellular areas (haematoxylin and eosin (H&E) x40). Inset image shows dense cellularity and mitoses in high power section (H&E staining x200).