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Magnetic resonance imaging in prostate cancer: the value of apparent diffusion coefficients for identifying malignant nodules

Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK

View larger version (59K): [in this window] [in a new window]   Figure 1. Patient with prostate cancer: malignant peripheral zone (PZ, black arrows) identified as a low signal-intensity region on conventional T2 weighted image (a) with the low signal-intensity central gland (CG; arrowhead) and high signal-intensity non-malignant PZ (white arrow) clearly identified. Regions of interest outlining the malignant nodule, CG and non-malignant PZ are shown in (b). The malignant nodule is seen as focal area of restricted diffusion (arrow) on (c) the apparent diffusion coefficient (ADC) map.

View larger version (10K): [in this window] [in a new window]   Figure 2. Outlines of a whole prostate gland drawn around theT2 weighted image (black) and corresponding diffusion weighted slice (grey). The outlines are overlaid to show the degree of distortion (a) before and (b) after pixel shifting to correct for left-right distortions in the phase-encode direction.

View larger version (10K): [in this window] [in a new window]   Figure 3. Box plot comparing apparrent diffusion coefficient(ADC) values in malignant peripheral zone (PZ), central gland (CG) and non-malignant PZ.