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First published online August 17, 2006
British Journal of Radiology (2006) 79, 991-998
© 2006 British Institute of Radiology
doi: 10.1259/bjr/10893584
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The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using {gamma}-rays or reactor thermal neutrons

S Masunaga, MD, PhD 1 Y Sakurai, PhD 4 K Nagata, MD, PhD 1 M Suzuki, MD, PhD 1 A Maruhashi, PhD 2 Y Kinashi, MD, PhD 3 H Nagasawa, PhD 5 Y UTO, PhD 6 H Hori, PhD 6 and K Ono, MD, PhD 1

1 Radiation Oncology Research Laboratory, 2 Division of Radiation Life Science, 3 Division of Radiation Safety, Research Reactor Institute, Kyoto University, Osaka, 4 Department of Physics, Faculty of Medicine, Sapporo Medical University, Sapporo, 5 Laboratory of Pharmaceutical Chemistry, Gifu Pharmaceutical University, Gifu, 6 Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, Tokushima, Japan


Figure 1
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  		Figure 1. The clonogenic cell survival curves after{gamma}-ray irradiation (left panel) or reactor thermal neutron beam irradiation (right panel) with conventional dose-rate irradiation (CDRI) or reduced dose-rate irradiation (RDRI) in combination with tirapazamine (TPZ) or without TPZ. TPZ was given as a single intraperitoneal injection (i.p.) or by continuous subcutaneously administration (cont.). Bars represent standard deviations.

 

Figure 2
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  		Figure 2. The normalized micronucleus frequencies after{gamma}-ray irradiation with conventional dose-rate irradiation (CDRI) or reduced dose-rate irradiation (RDRI) in combination with tirapazamine (TPZ) or without TPZ in the total (left panel) and Q (right panel) tumour cell populations. TPZ was given as a single intraperitoneal injection (i.p.) or by continuous subcutaneously administration (cont.). Bars represent standard deviations.

 

Figure 3
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  		Figure 3. The normalized micronucleus frequencies after reactor thermal neutron beam irradiation with conventional dose-rate irradiation (CDRI) or reduced dose-rate irradiation (RDRI) in combination with or without tirapazamine (TPZ) administration in the total (left panel) and Q (right panel) tumour cell populations. TPZ was given as a single intraperitoneal injection (i.p.) or by continuous subcutaneously administration (cont.). Bars represent standard deviations.

 




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