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MRI histopathology correlation of N-phenylanthranilic acid induced nephropathy in rats

AstraZeneca Pharmaceuticals Alderley Park Macclesfield Cheshire UK

View larger version (96K): [in this window] [in a new window]   Figure 1. (a) Coronal spin echo MR image of a left kidney from a control animal. (b,c) Coronal spin echo image of left kidney from NPAA treated animals. The kidneys in (b,c) show increased size, loss of clear demarcation of corticomedullary junction and fines radial bands with alternating high and low signal. (a) A swollen medulla.

View larger version (59K): [in this window] [in a new window]   Figure 2. (a) Axial spin echo MR image of a left kidney from a control animal. (b) Axial spin echo images of left kidney from a NPAA treated animal showing a loss of the demarcation of corticomedullary junction.