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British Journal of Radiology (2006) 79, e84-e87
© 2006 British Institute of Radiology
doi: 10.1259/bjr/62250180
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Unusual case of well-differentiated papillary thyroid carcinoma lacking thyroglobulin expression while still concentrating radioiodine

B Singh, PhD1, R Bollmann, MD2, H Ahmadzadehfar, MD3, H J Biersack, MD3 and S Ezziddin, MD3

1 Department of Nuclear Medicine, PGIMER, Chandigarh-160012, India, 2 Institute for Pathology, Heilsbachstr. 15, 53123 Bonn-Duisdorf, Germany, 3 Department of Nuclear Medicine, Sigmund-Freud-Str. 25, 53105, Bonn, Germany


Figure 1
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  		Figure 1. CT chest demonstrating multiple bilateral lung lesions.

 

Figure 2
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  		Figure 2. Anti-thyroglobulin (Tg) immunostaining showing no evidence of Tg expression in the tumour specimen.

 

Figure 3
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  		Figure 3. Anti-thyroglobulin (Tg) immunostaining of a positive control with strong focal reaction.

 

Figure 4
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  		Figure 4. First therapeutic(100 mCi) whole body radioiodine scan (anterior view) showing multiple radioiodine avid lesions in both lungs.

 

Figure 5
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  		Figure 5. Post-therapeutic whole body radioiodine scan (anterior view) after the second therapy (300 mCi) showing reduction in the size and number of radioiodine avid lesions (left > right) in both lungs.

 

Figure 6
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  		Figure 6. Repeat chest CT scan after the third radioiodine therapy showing significant size reduction in the lung lesions.

 

Figure 7
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  		Figure 7. Fifth post-therapy whole body radioiodine scan (anterior view) showing no residual disease.

 




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