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First published online April 26, 2006
British Journal of Radiology (2006) 79, 652-658
© 2006 British Institute of Radiology
doi: 10.1259/bjr/25349497
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Usefulness of diffusion/perfusion-weighted MRI in patients with non-enhancing supratentorial brain gliomas: a valuable tool to predict tumour grading?

G G Fan, PhD, MD Q L Deng, MD Z H Wu, MD and Q Y Guo, PhD, MD

Department of Radiology, Second Hospital of China Medical University, No.36 Sanhao St., Heping Dist., Shenyang, Liaoning,110004, People's Republic of China


Figure 1
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  		Figure 1. MRI and diffusion weighted imaging(DWI) from a patient with anaplastic astrocytoma. (a) T2 weighted image. (b) T1 weighted MR image with contrast material. (c) DWI (b = 1000). (d) Apparent diffusion coefficient (ADC). The tumour exhibited typical hyperintense on T2 weighted images; peritumoural oedema and mass effect was present; no contrast enhancement. On DWIs (b = 1000), the signal intensity in the solid portion of the tumour was hyperintense with respect to the white matter; lower ADC values were present in the solid portions of high grade gliomas.

 

Figure 2
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  		Figure 2. Perfusion weighted imaging(PWI) and histopathological photograph from a patient with anaplastic astrocytoma (same patient as in Figure 1Go). (a) Relative cerebral blood volume (rCBV) colour map. (b) Signal-intensity time-curve. (c) Histopathological photograph. rCBV maps were inhomogeneous with various increases of signal intensity in both solid portion and peritumoural region of tumour. Histopathological photograph of tumour confirmed the diagnosis of anaplastic astrocytoma.

 

Figure 3
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  		Figure 3. MRI and diffusion weighted imaging(DWI) from a patient of anaplastic astrocytoma. (a) T2 weighted image. (b) T1 weighted MR image with contrast material. (c) DWI (b = 1000). (d) Apparent diffusion coefficient (ADC). The tumour exhibited typical hyperintensity on T2 weighted images; infiltration of the tumour producing nodular thickening of the grey matter was observed. The tumour did not produce significant contrast enhancement on visual assessment, On DWIs (b = 1000), the signal intensity in the solid portion of the tumour was hyperintense with respect to the white matter; lower ADC values were present in the solid portions of high grade gliomas.

 

Figure 4
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  		Figure 4. Perfusion weighted imaging(PWI) and histopathological photograph from a patient with anaplastic astrocytoma (same patient as in Figure 3Go). (a) Relative cerebral blood volume (rCBV) colour map. (b) Signal-intensity time-curve. (c) Histopathological photograph. rCBV maps were inhomogeneous with various increases of signal intensity in solid portion of tumour. Histopathological photograph of tumour confirmed the diagnosis of anaplastic astrocytoma.

 

Figure 5
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  		Figure 5. MRI and diffusion weighted imaging(DWI) from a patient with low-grade oligodendrogliomas. (a) T1 weighted image. (b) T2 weighted image. (c) DWI (b = 1000). (d) Apparent diffusion coefficient (ADC). The tumour exhibited inhomogeneous with various increase of signal intensity on both T2 weighted image and DWI.

 

Figure 6
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  		Figure 6. Perfusion weighted imaging(PWI) and histopathological photograph from a patient with low-grade oligodendrogliomas (same patient as in Figure 5Go). (a) Relative cerebral blood volume (rCBV) colour map. (b) Signal-intensity time-curve. (c) Histopathological photograph. The signal intensity in both peritumoural region and solid portion of tumour was homogeneous on rCBV map. Histopathological photograph of tumour confirmed the diagnosis of oligodendrogliomas (Grade II).

 




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