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Survival and initial chromatid breakage in normal and tumour cells exposed in vitro to gamma rays and carbon ions at the HIRFL

¹ Institute of Modern Physics, Chinese Academy of Sciences, ² Life Science School of North West Normal University, ³ Life Science School of Lanzhou University, Lanzhou, China

View larger version (12K): [in a new window]   Figure 1. Survival curve of SMMC7721 and L02 cells exposed to gamma rays and carbon ions. Survival fraction value is the mean±standard deviation. The survival curve of cells exposed to gamma rays was linear-quadratic, and was almost linear when cells were exposed to carbon ions. The survival fraction of SMMC7721 cells and L02 cells are significantly different when exposed to either gamma rays or carbon ions.

View larger version (14K): [in a new window]   Figure 2. Correlation between absorbed dose and chromatid breaks. In both(a) L02 and (b) SMMC7721 cell lines, more isochromatid than chromatid breaks were seen when cells were exposed to carbon ions, and fewer isochromatid than chromatid breaks seen when cells were exposed to gamma rays. Fewer breaks were induced in L02 cells than in SMMC7721 cells after either carbon ion or gamma ray exposure. All the data were the mean±standard deviation.

View larger version (20K): [in a new window]   Figure 3. Proportion of two types of chromatid breaks. For cells irradiated with gamma rays, the number of chromatid breaks in both cell lines was much more than that of isochromatid breaks; for cells exposed to carbon ions, the isochromatid breaks were much more frequent than the chromatid breaks. They were significantly different.