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British Journal of Radiology (2006) 79, 409-414
© 2006 British Institute of Radiology
doi: 10.1259/bjr/16265085
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Effect of ticlopidine in the prevention of radiation enteropathy

S Akyurek, MD1, L Atahan, MD2, M Cengiz, MD2, C Sokmensuer, MD3, I Haberal, MD4, F Yildiz, MD2 and C Onal, MD1

1 Department of Radiation Oncology, Ankara University School of Medicine, Ankara, Departments of, 2 Radiation Oncology and, 3 Pathology, Hacettepe University School of Medicine, Ankara and, 4 ENT and Head and Neck Surgery Department, Health Ministry Ankara Education and Training Hospital, Ankara, Turkey


Figure 1
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  		Figure 1. Weight changes as a function of time after irradiation.

 

Figure 2
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  		Figure 2. Median radiation injury scores as a function of time after irradiation.

 

Figure 3
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  		Figure 3. Radiotherapy(RT) alone group. Specimen exhibits extensive mucosal ulceration and vascular sclerosis, 26 weeks after irradiation (vs, vascular sclerosis; ul, ulcer; s, serosa).

 

Figure 4
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  		Figure 4. Radiotherapy+ticlopidine (RT+T) group. Specimen exhibits mild thickening of muscularis mucosa, 26 weeks after irradiation (vs, vascular sclerosis; m, muscularis mucosa).

 

Figure 5
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  		Figure 5. Macroscopic appearance of the radiotherapy(RT) alone group 26 weeks after irradiation demonstrates apparent bowel wall thickening, adhesion and stenosis. Arrows show suturated specimen (vs, vascular sclerosis; ul, ulcer; s, serosa).

 

Figure 6
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  		Figure 6. Macroscopic appearance of the radiotherapy+ticlopidine (RT+T) group 26 weeks after irradiation demonstrates mild bowel wall thickening. Arrows show suturated specimen (vs, vascular sclerosis; m, muscularis mucosa).

 




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