BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
British Journal of Radiology (2006) 79, 71-75
© 2006 British Institute of Radiology
doi: 10.1259/bjr/50464795
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miura, M
Right arrow Articles by Laissue, J A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miura, M
Right arrow Articles by Laissue, J A

Radiosurgical palliation of aggressive murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams

M Miura, PhD 1 H Blattmann, PhD 2 E Bräuer-Krisch, BEng 3 A Bravin, PhD 3 A L Hanson, PhD 1 M M Nawrocky, BA 1 P L Micca, BS 1 D N Slatkin, MD 1,4 and J A Laissue, MD 4

1 Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA, 2 Niederwiesstrasse 13C, Untersiggenthal, Switzerland, 3 European Synchrotron Radiation Facility, 6 Rue Jules Horowitz, BP 220, Grenoble, France and 4 Pathologisches Institut der Universität Bern, Murtenstrasse 31, Bern, Switzerland


Figure 1
View larger version (130K):

[in a new window]
  		Figure 1. Photograph of anaesthetized female C3H mouse bearing a leg squamous-cell carcinoma (SCCVII) carcinoma taped to Plexiglas® block, readied for microbeam radiosurgery (MBRS) at the European Synchrotron Radiation Facility (ESRF).

 

Figure 2
View larger version (6K):

[in a new window]
  		Figure 2. A Plexiglas® polymethylmethacrylate block (thick black outline) served as a "saddle" for the mouse, viewed as it would be by an observer directly above it. The mouse was anaesthetized and placed prone on the block for its first tumour irradiation. In this figure, the outline of the mouse is represented by an ellipse. Two black dots represent its eyes. To avoid irradiating its left foreleg, the 150 mm long axis of the block was rotated 5° (about a vertical axis through the centre of the block) clockwise from the reference 0° microbeam direction. The microbeam array, symbolized by thin arrows, was propagated in a thin, wide, slightly divergent fan-beam, substantially in a horizontal plane, represented here as the plane of this page. The second irradiation was implemented after the block was rotated 95° clockwise from the 0° reference direction about the same vertical axis.

 

Figure 3
View larger version (13K):

[in a new window]
  		Figure 3. Kaplan-Meier graphs of C3H mice bearing aggressive squamous-cell carcinoma (SCCVII) leg carcinomas irradiated with various radiation modalities. The on-centre distances for microbeam radiosurgery (MBRS)-irradiations were 200 µm. Mice euthanized due to foot/leg damage were not distinguished from those euthanized due to tumour overgrowth: (a) Survival graphs of mice bearing SCCVII carcinomas treated with seamless 25 Gy or 35 Gy skin-entrance doses of X-rays in comparison with unirradiated controls. (b) Survival graphs of similar mice in MBRS groups (1–6) with skin entrance doses of 442 Gy, 625 Gy, and 884 Gy at 35 µm and 442 at 70 µm beam width. "Al" designates a 16 mm-thick aluminium filter placed upstream from the collimator.

 

Figure 4
View larger version (25K):

[in a new window]
  		Figure 4. Average relative tumour volumes of the various microbeam radiosurgery (MBRS)-irradiated and control mice. The lower tumour volumes noted in groups 3 to 6 relate to the fact that those tumours had regressed to relatively small or undetectable volumes when most of the mice had to be euthanized due to severe radiodermatitis of the inner thigh.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 2006 by the British Institute of Radiology.