This Article Abstract Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Simick, M K Articles by Lilge, L Search for Related Content PubMed PubMed Citation Articles by Simick, M K Articles by Lilge, L

Optical transillumination spectroscopy to quantify parenchymal tissue density: an indicator for breast cancer risk

¹ Department of Medical Biophysics, University of Toronto, ² Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada and ³ University Health Network, 610 University Avenue, Toronto, Ontario, M6G 2M9 Canada

View larger version (76K): [in a new window]   Figure 1. (a) Mammogram showing high parenchymal tissue density. (b) Mammogram with low parenchymal tissue density. Example of mammogram (c) with regions of interest (d) extracted, starting top left and going clockwise, centre medial, distal and lateral position.

View larger version (44K): [in a new window]   Figure 2. (a) Schematic of transmission measurement system. (b) Measurement of the C=centre position in volunteer. The other three measurement positions are denoted as D=distal, M=medial and L=lateral. Note: the minimal point compression of the breast between source optode and support plate.

View larger version (15K): [in a new window]   Figure 3. Sample spectra corresponding to regions of interest with (a) <10% (b) 45–55% and (c) >90% tissue density. All spectra were corrected for tissue thickness and the spectrophotometer transfer function.

View larger version (29K): [in a new window]   Figure 4. Partial least squares regression predicted vs actual tissue density for (a, b) Reader 1 and (c, d) Reader 2. (a, c) Results for the PLS training and (b, d) for the validation spectra. Regression line and 95% confidence intervals are indicated.

View larger version (15K): [in a new window]   Figure 5. Thickness-corrected transillumination spectra from a single volunteer. Shown are the bilateral four quadrant measurements, indicating a high degree of symmetry between the breast tissue in the respective bilateral quadrants.

View larger version (15K): [in a new window]   Figure 6. Symmetry tissue density for the centre region of interest (ROI) determined by mammography (open circles) and by partial least squares (PLS) prediction (solid squares) for reader 1.

View larger version (22K): [in a new window]   Figure 7. Graph of partial least squares analysis actual vs predicted plots for (a) reader 1 and (b) reader 2. Week 1 solid rhombus, week 2 solid square, week 3 open triangle and week 4 open circle.