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The potential for mathematical modelling in the assessment of the radiation dose equivalent of cytotoxic chemotherapy given concomitantly with radiotherapy

¹ Department of Clinical Oncology, Queen Elizabeth University Hospital, Birmingham B15 2TH and ² Department of Radiation Physics and Radiobiology, Charing Cross Hospital, London W6 8RF, UK

View larger version (18K): [in a new window]   Figure 1. Plot of sensitizer enhancement ratios (s) against number of sensitized fractions out of a total of 30; the / ratio is assumed to be 15 Gy. The results are for an assumed improvement in tumour control probability from 45 to 67%.

View larger version (28K): [in a new window]   Figure 2. Plot of individual tumour control probability against total radiation dose for variable chemotherapy biological effective shown as ChemoRx BED.

View larger version (26K): [in a new window]   Figure 3. Relationship in a population of 500 tumours between tumour control probability and total radiation dose with assumed additional chemotherapy biological effective dose equivalents, shown as ChemoRx BED.

View larger version (17K): [in a new window]   Figure 4. Example of relationship between tumour cure probability and the additional biological effective dose (BED) associated with chemotherapy: the parameters are those in example 3 in Table 2.

View larger version (26K): [in a new window]   Figure 5. Results of random sampling techniques in a virtual clinical trial for cervix cancer, with 200 patients per point. Schedules and legend codes are given in Table 2, parameters in Table 1. The addition of concomitant Cis-platinum is designated by "+P".