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A phase I trial of stereotactic external beam radiation for subfoveal choroidal neovascular membranes in age-related macular degeneration

Departments of ¹ Ophthalmology and ² Radiation Oncology, UC Davis, Sacramento, CA, USA

View larger version (21K): [in a new window]   Figure 1. The distribution of mean visual acuity (VA) change (y-axis, Log MAR) of patients in the different dosage categories (x-axis, Gy) 12 months after radiation. The mean VA before treatment was 0.82±0.35, with no significant difference among dosage groups. The mean VA was 0.83±0.36 at 6 months and 0.89±0.33 at 12 months. There was no significant change in VA in any treated patient.

View larger version (46K): [in a new window]   Figure 2. The percentage of patients (y-axis) who lost 3 and 6 at 12 months following treatment as distributed among the various treatment groups (x-axis). Overall, 18% of patients lost 3 lines of VA and 10% lost 6 lines. The VA remained within ±3 lines of the baseline value in 82% of patients.