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Differentiation of focal nodular hyperplasia and hepatocellular adenoma by contrast-enhanced ultrasound

¹ 1st Department of Internal Medicine, Caritas Hospital Bad Mergentheim, Uhlandstr. 7, 97980 Bad Mergentheim, ² 2nd Department of Internal Medicine and ³ Senckenberg Center of Pathology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D-60590 Frankfurt am Main, Germany

View larger version (35K): [in a new window]   Figure 1. Contrast-enhanced phase inversion ultrasound imaging of a patient with focal nodular hyperplasia. (a) Contrast-enhanced phase inversion ultrasound scanning 8–22 s (onset of arterial phase) after administration of SonoVue® revealed an hyperechoic hypervascular liver tumour with radial vascular architecture. (b) During the portal venous phase (onset 12–30 s after administration of SonoVue®) a pronounced enhancement could be detected by contrast-enhanced phase inversion ultrasound scanning. Hepatic artery (HA) and portal vein (PV) are indicated.

View larger version (35K): [in a new window]   Figure 2. Contrast-enhanced phase inversion ultrasound of a patient with hepatocellular adenoma (arrows). (a) Contrast-enhanced phase inversion ultrasound scanning revealed only arterial phase enhancement for 10 s (10–20 s) after administration of SonoVue®. (b) At the end of the arterial phase (22 s after administration of SonoVue®) a slightly hypoechoic liver tumour was detected by contrast-enhanced phase inversion ultrasound and no portal venous sinusoidal enhancement was observed.