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British Journal of Radiology (2005) 78, 335-337
© 2005 British Institute of Radiology
doi: 10.1259/bjr/24426084

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Further evidence for biological effects resulting from ionizing radiation doses in the diagnostic X-ray range

S Anoopkumar-Dukie, MSc1, A McMahon, BSc, HND2, A Allshire, PhD1 and T J Conere, MSc, PhD2

1 Department of Pharmacology and Therapeutics, University College Cork, Wilton, Cork, Ireland and 2 Medical Physics Department, Cork University Hospital, Wilton, Cork, Ireland



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Figure 1. (a) Response of HeLa cells to low-dose X-ray irradiation, measured 7 days post irradiation as capacity for resazurin reduction. Data are means and standard deviation (SD) for three independent experiments, except for control (zero dose) and 7.5 mGy where n=6. (b) Protection against the irradiation effect at 7.5 mGy by LNMMA (1 mM) but not by ascorbic acid (AA, 200 µM) or p38 MAPK inhibitor SB203580 (10 µM). Data are means and (SD) for three independent experiments.

 





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