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Comparison of the hepatic perfusion index measured with gadolinium-enhanced volumetric MRI in controls and in patients with colorectal cancer

¹ Departments of Radiology, ² Neuroimaging and ³ Medical Engineering and Physics, King's College Hospital, Denmark Hill, London SE5 9RS, UK

View larger version (86K): [in a new window]   Figure 1. Axial section from one of the colorectal cancer patients showing extracted time-course data for regions of interest in the liver, spleen and aorta. The liver curve demonstrates significant early enhancement prior to the peak of the spleen curve, consistent with an increase in the hepatic component of perfusion and a corresponding decrease in the portal component.

View larger version (8K): [in a new window]   Figure 2. Median and interquartile ranges for the hepatic perfusion index (HPI) measured in patients with colorectal metastases and control subjects (p<0.005, unpaired t-test).

View larger version (9K): [in a new window]   Figure 3. Median and interquartile ranges for the relative portal perfusion measured in patients with colorectal metastases and control subjects (p<0.005, unpaired t-test).