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Measurement of cartilage volumes in rheumatoid arthritis using MRI

¹ Department of Medical Physics & Bioengineering, Bristol General Hospital, Guinea Street, Bristol BS1 6SY, ² Rheumatology Unit, University of Bristol Division of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, ³ Division of Imaging Sciences and Biomedical Imaging, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, ⁴ MRC Health Services Research, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, ⁵ Respiratory and Inflammation Research, ⁶ Enabling Science Technology and Information, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG and ⁷ Department of Clinical Radiology, Bristol Royal Infirmary, Bristol BS2 8HW, UK

View larger version (60K): [in a new window]   Figure 1. (A) A typical sagittal image slice taken from a patient with rheumatoid arthritis, showing cartilage loss (arrow i), bony erosion (arrow ii) and joint effusion (arrow iii). (B) The resulting three-dimensional (3D) segmentation of the femoral cartilage, showing cartilage loss (arrow iv).

View larger version (13K): [in a new window]   Figure 2. Total cartilage volume in the knee in 17 rheumatoid arthritis patients over 12 months ( male; • female).