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Second cancers following radiotherapy: a suggested common dosimetry framework for therapeutic and concomitant exposures

Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK

View larger version (22K): [in a new window]   Figure 1. Cancer incidence in England 1996–2000; all cancers (excluding non-melanoma skin cancer), by sex and single year of age at diagnosis. Courtesy of Dr S Rowan, London, Office for National Statistics 2003.

View larger version (35K): [in a new window]   Figure 2. Percentage incidence of carcinogenesis 20 years after irradiation given by Lindsay et al [10] (A) for various levels of cell re-population; (B) for various values of the intrinsic cellular radiosensitivities and with =/10; (C) for various values of the spontaneous mutation rate µ; (D) for various values of the mutational radiosensitivities and with =/10. In each of (A), (B), (C) and (D) only one parameter changes while the others take the values =0.25 Gy–1, =0.025 Gy–2, µ=2.10–8 month–1, =10–5 Gy–1, =10–6 Gy–2. Reproduced from Lindsay et al [10] with permission.