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British Journal of Radiology (2004) 77, 1027-1035
© 2004 British Institute of Radiology
doi: 10.1259/bjr/83720350
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Radiprotective effect of abana, a polyherbal drug following total body irradiation

M S Baliga1, G C Jagetia1, P Venkatesh1, R Reddy2 and J N Ulloor3

1 Department of Radiobiology, Kasturba Medical College, Manipal-576 104, 2 College of Pharmaceutical Sciences, Manipal-576 104, Karnataka, India and 3 Department of Psychiatry and Program in Behavioral Neuroscience, Boston University School of Medicine, Boston, MA, USA



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  		Figure 1. Kaplan-Meir's estimate of survival of mice treated with 20 mg kg–1 body weight of abana before exposure to various doses of gamma-radiation. (a) 8 Gy, (b) 9 Gy, (c) 10 Gy, (d) 11 Gy and (e) 12 Gy of radiation. {blacksquare}: double distilled water+irradiation; {circ}: abana+irradiation.

 


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  		Figure 2. Effect of 20 mg kg–1 of abana on the radiation-induced mortality on day 10 post-irradiation in the mice exposed to different doses of gamma-radiation. {blacksquare}: double distilled water+irradiation and •: abana+irradiation (95% confidence limits).

 


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  		Figure 3. Effect of 20 mg kg–1 of abana on the radiation-induced mortality on day 30 post-irradiation in the mice exposed to different doses of gamma-radiation. {blacksquare}: double distilled water+irradiation and •: abana+irradiation (95% confidence limits).

 


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  		Figure 4. Alteration in the (a) glutathione and (b) lipid peroxidation levels in the liver of mice treated with 20 mg kg–1 abana before exposure to different doses of gamma-radiation.

 


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  		Figure 5. Influence of various doses of abana (ABE) on the scavenging of different free radicals in vitro. (a) Hydroxyl, (b) DPPH, (c) ABTS and (d) NO.

 




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