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British Journal of Radiology (2004) 77, 953-956
© 2004 British Institute of Radiology
doi: 10.1259/bjr/51760601
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The kidney in paroxysmal nocturnal haemoglobinuria: MRI findings

J Rimola, MD, J Martín, MD, PhD, J Puig, MD, A Darnell, MD and A Massuet, MD

Unitat de Diagnòstic per la Imatge d’Alta Tecnologia (UDIAT), Corporació Sanitària del Parc Taulí, 08208 Sabadell, Spain



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  		Figure 1. Case one. (a) Axial T1 weighted in-phase gradient-echo image of the kidneys showing notably low signal intensity of the renal cortex. Note the medullary area is not affected by the iron deposition. (b) Coronal T2 weighted half-Fourier single-shot turbo spin echo (HASTE) image. The renal cortex is of low signal intensity compared with the renal medullary zone.

 


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  		Figure 2. Case two. (a) Axial T1 weighted in-phase gradient-echo slice showing a reversal of renal cortex-medulla differentiation with low signal intensity of the renal cortex. (b) Coronal half-Fourier single-shot turbo spin echo (HASTE) image of both kidneys shows the cortical zones with low signal intensity and the medullary area with normal signal intensity.

 


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  		Figure 3. Case three. (a) T1 weighted axial gradient-echo image shows the cortical area of the kidneys with low signal intensity compared with the medullary zone, which maintains the intermediate signal intensity of a normal kidney. (b) The T2 weighted image shows the kidneys with a dark cortex due to iron deposition.

 


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  		Figure 4. Case four. A very dark renal cortical zone compared with the medullary area is seen in the T1 weighted image.

 




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