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Synthesis of copper octabromotetracarboranylphenylporphyrin for boron neutron capture therapy and its toxicity and biodistribution in tumour-bearing mice

Medical Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA

View larger version (14K): [in a new window]   Figure 1. Structures of CuTCPBr, its precursor CuTCPH and its congener CuTCP.

View larger version (15K): [in a new window]   Figure 2. Boron concentrations (µg B per g wet tissue) (mean±SD) in tumour, blood and brain at various time points (2, 4 or 6 days after last injection) after a dose of 215–30 mg kg–1 CuTCPBr (47–50 mg B kg–1) (n=7) in 6 i.p. injections over 2 days (a) in BALB/c mice bearing EMT-6 carcinomas and (b) in C3H mice bearing SCCVII carcinomas.

View larger version (18K): [in a new window]   Figure 3. Boron concentrations (µg B per g wet tissue) (mean±SD) in tumour, blood and brain at various time points (1, 3 or 6 h after a single i.p. injection) after a dose of 790 mg kg–1 BPA fructose complex (38 mg B kg–1) in (a) in BALB/c mice bearing EMT-6 carcinomas and (b) in C3H mice bearing SCCVII carcinomas.