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Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury

¹ Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow Region, 142292, Russia and ² Department of Clinical Oncology, Oxford Radcliffe Hospitals NHS Trust, The Churchill Hospital, Oxford OX3 7LJ, UK

View larger version (14K): [in a new window]   Figure 1. Time-related changes in endothelial cell number, relative to numbers in unirradiated control rats, after local brain irradiation with 25 Gy of X-rays. Animals received Gammaphos (•) before irradiation, or radiation alone (o). Error bars indicated±standard error.

View larger version (10K): [in a new window]   Figure 2. Time-related changes in blood vessel density, relative to density in unirradiated control rats, after local brain irradiation with 25 Gy of X-rays. Animals receiving Gammaphos prior to exposure () or irradiation only (). Error bars indicated±standard error.

View larger version (12K): [in a new window]   Figure 3. Time-related changes in the percentage incidence of both necrosis (, ) and vascular abnormalities (•, o) in rat brain after irradiation with 25 Gy of X-rays. For both parameters closed symbols correspond to data from animals receiving Gammaphos prior to exposure; open symbols correspond to data for the group of animals receiving irradiation only. Error bars indicated±standard error.