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Molecular imaging using hyperpolarized ¹³C

¹ Amersham Health R&D AB, Medeon, SE-205 12 Malmö and ² Department of Experimental Research, Malmö University Hospital, SE-205 02 Malmö, Sweden

View larger version (18K): [in a new window]   Figure 1. Pictorial description of the orientation of the nuclei at thermal equilibrium and in the hyperpolarized state. In the figure, the magnetic field (B0) is directed vertically upwards.

View larger version (96K): [in a new window]   Figure 2. During the dynamic nuclear polarization process, polarization is transferred from the electrons of the doping material to the 13C nuclei by means of microwave irradiation.

View larger version (22K): [in a new window]   Figure 3. The four possible orientations of the nuclear spin in the hydrogen molecule.

View larger version (29K): [in a new window]   Figure 4. (a) A substrate molecule containing 13C is hydrogenated with parahydrogen. (b) The spin order of the parahydrogen molecule is converted to nuclear polarization of the 13C nucleus, via a diabatic field cycling scheme.

View larger version (101K): [in a new window]   Figure 5. (a) Three-dimensional 3He image of a rat lung (central slice and surface rendering). (b) The corresponding quantitative ventilation map calculated according to the method described by Deninger et al [38].

View larger version (51K): [in a new window]   Figure 6. A series of trueFISP 13C images, showing the lungs of a pig after injection of a hyperpolarized 13C imaging agent. The imaging sequence was repeated with 1 s intervals.

View larger version (14K): [in a new window]   Figure 7. Schematic drawing of the trueFISP sequence.

View larger version (73K): [in a new window]   Figure 8. Images depicting the distribution of the injected hyperpolarized 13C imaging agent at different times after the injection. The delay between injection and imaging is indicated at the top of each image.