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Molecular imaging using magnetic resonance: new tools for the development of tumour therapy

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK

View larger version (164K): [in a new window]   Figure 1. 1H MR images from fixed mouse embryos. The top image is from a Pkd1 knockout embryo and the bottom is from a control. Regions of oedema and haemorrhage in the knockout are marked by arrows. Figure taken, with permission, from [6].

View larger version (38K): [in a new window]   Figure 2. Sequential 1H MR spin echo images (echo time=30 ms) obtained from an apoptotic tumour following injection of the C2-SPIO (superparamagnetic iron oxide) contrast agent. The images were acquired over a period of nearly 2 h. The region of negative contrast, marked by the arrow, was coincident with a region of apoptotic cells observed by histological analysis of a corresponding tumour section obtained post mortem. Figure modified, with permission, from [25].

View larger version (116K): [in a new window]   Figure 3. 1H MR image of a rat brain obtained ex vivo, 7 days after the injection of superparamagnetic iron oxide (SPIO)-labelled oligodendrocytes (right side of image) and unlabelled cells on the contralateral side. Figure modified, with permission, from [49].