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Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity

Departments of ¹ Diagnostic Radiology, ² Neurology and ³ Haematology, The Catholic University of Korea, Seoul, Korea

View larger version (101K): [in a new window]   Figure 1. 22-year-old man who underwent bone marrow transplantation for severe aplastic anaemia. (a) T2 weighted MRI at the level of basal ganglia and splenic portion of corpus callosum shows bilateral high signal intensities involving cortical and subcortical white matter in both occipital lobes (arrows). At left basal ganglia, haemorrhagic dark signal intensity with surrounding oedema is demonstrated. (b) Diffusion-weighted image with superior–inferior direction of diffusion encoding gradient at the same level of (a) demonstrates also increased signal intensities (arrows). (c) ADC mapping obtained through the same level of (b) demonstrates increased signal intensity in right occipital lobe, representing vasogenic oedema (arrow). There is no area of decreased signal intensity in both occipital lobes.