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High resolution MRI of the brain at 4.7 Tesla using fast spin echo imaging

¹ The Wellcome Trust High Field MR Research Laboratory, Department of Medical Physics and Bioengineering, University College London, 12 Queen Square, London WC1N 3AR, ² MR Research Systems, Unit 5, Merrow Lane, Guildford, Surrey GU4 7BF and ³ Division of Neuroradiology, Institute of Neurology, Queen Square, London WC1N 3BG, UK

View larger version (107K): [in a new window]   Figure 1. Fast spin echo high resolution transverse MRIs of a healthy volunteer (male, 29 years) displayed with conventional grey scale. Slice thickness 2 mm, in-plane resolution 469 µm x 469 µm, number of slices 34, total acquisition time 11 min 20 s. Figures (a) to (d) display four different sections from the top of the brain to the level of the substantia nigra. The white rectangle in Figure 1d indicates the region expanded in Figure 2d.

View larger version (120K): [in a new window]   Figure 2. Same images as in Figure 1, presented with an inverted grey scale (with Figure 2d showing an expanded region from Figure 1d). Structures mentioned in the text are highlighted with grey arrows: tails of caudate nuclei and Virchow-Robin (VR) spaces (b); medullary lamina (c); fornix, mammillary tract, red nucleus and substantia nigra (d).

View larger version (98K): [in a new window]   Figure 3. Fast spin echo high resolution coronal MRIs of (a) male, 30 years and (b) and (c) female, 34 years, displayed with an inverted grey scale. Slice thickness 2 mm, in-plane resolution 391 µm x 521 µm, number of slices 17, total acquisition time 5 min 40 s. Grey arrows indicate some of the readily visible Virchow-Robin (VR) spaces. The enlarged inset (c) from (b) shows the left hippocampus, with grey arrows indicating various internal structures (alveus, cornu ammonis, gyrus dentatus).